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This problem has been underscored by the high degree of variation in patient response to biologic therapy, where some patients respond dramatically and others either fail treatment or have suboptimal responses

Probiotic use before and throughout the eradication treatment, especially when lasting more than 2 weeks, showed superior outcomes, with the best results observed when probiotics were combined with bismuth quadruple therapy (Shi et al., 2019)

Mutagenesis 7:2530 Bianchi MW, Roux C, Vartanian N (2002) Drought regulation of GST8, encoding the Arabidopsis homologue of ParC/Nt107 glutathione transferase/peroxidase

Another recent study showed that the overexpression of the miRNAs miR-126-3p and5p was able to reduce the expression of proinflammatory cytokines and adhesion molecules and hence attenuate the BBB disruption in the acute stage of AIS (265)